器官移植Issue(4)：249-253,5.DOI:10.3969/j.issn.1674-7445.2015.04.009
肾移植术后人类微小病毒 B19感染致纯红细胞再生障碍性贫血2例并文献复习
Pure red cell aplasia caused by human parvovirus B19 infection after renal transplantation:a report of ;2 cases and literature review
摘要
Abstract
Objective To investigate the diagnosis and treatment characteristics of pure red cell aplasia (PRCA)caused by human parvovirus (HPV)B19 infection after renal transplantation.Methods Two cases with PRCA caused by HPV B19-induced after renal transplantation,who were treated in the Department of Organ Transplantation,Nanfang Hospital,Southern Medical University,were summarized.Combined with literature review,the clinical characteristics,diagnostic method,course of treatment and prognosis of such disease were investigated.Results Two renal transplant recipients developed severe anemia early after transplantation with progressive deterioration and failed transfusion therapy.Other causes of anemia were ruled out and two patients were diagnosed as PRCA caused by HPV B19 infection according to bone marrow aspiration and biopsy as well as HPV DNA detection by fluorescent polymerase chain reaction (PCR).The symptoms of anemia were improved significantly after adjustment of immunosuppressive treatment protocol and intravenous immunoglobulin (IVIG).Conclusions For patients with unexplained and progressed anemia early after renal transplantation,especially those complicated with reticulocyte deficiency,the possibility of PRCA caused by HPV B19 infection shall be considered.The results of bone marrow aspiration and fluorescent PCR are the main bases for diagnosing PRCA.Immunosuppressive agents reduction and application of IVIG are the major treatment measures.Most of patients have great prognosis after treatment,but this disease is likely to recur.关键词
肾移植/人类微小病毒 B19/纯红细胞再生障碍性贫血/免疫球蛋白/复发Key words
Renal transplantation/Human parvovirus B19/Pure red cell aplasia/Immunoglobulin/Relapse分类
医药卫生引用本文复制引用
黄森林,于立新,邓文锋,郭进明,苗芸..肾移植术后人类微小病毒 B19感染致纯红细胞再生障碍性贫血2例并文献复习[J].器官移植,2015,(4):249-253,5.基金项目
南方医科大学南方医院院长基金项目（2013B011）；全国大学生创新创业训练计划项目 （）
