四川精神卫生Issue(5)：385-389,5.DOI:10.3969/j.issn.1007-3256.2014.05.001
产后抑郁与分娩前后孕酮、雌二醇变化的相关性研究
Research of postpartum depression and progesterone, estradiol change before and after childbirth
摘要
Abstract
Objective To explore the impact of serum estradiol ( E2 ) , progesterone ( P) on the postpartum depression about a week before and after childbirth. Methods Selection 395 cases of maternal who saw a doctor in guiyang medical college affiliated hos-pital as the research object in March 2012 - September 2012, using the Edinburgh postnatal depression scale ( EPDS) to assess the postpartum depression, and uses the biotin method of double antibody sandwich enzyme-linked immunosorbent ( ELISA) determina-tion of maternal serum estradiol (E2), progesterone (P), serotonin (5-HT) level. Results ①Depression detected the number of 48 cases, detection rate of 12. 15% a week after childbirth. ②Female serum progesterone level difference after childbirth between de-pression with and without depression group was statistically significant (P<0. 05). ③The correlation analysis showed that the postpartum EPDS scores and prenatal serum estradiol level, prenatal postpartum serum progesterone level and postnatal progesterone, estradiol de-clines were positively correlated, and negatively correlated with postpartum 5-HT, estradiol levels (r= -0. 881~0. 881,P<0. 01).Conclusion Maternal serum progesterone, estradiol level declined obviously after delivery, female progesterone and estradiol dramatic drops were important biological factors on postpartum depression.关键词
雌二醇(E2)/孕酮(P)/5-羟色胺(5-HT)/产后抑郁Key words
Estradiol (E2)/Progesterone (P)/Serotonin (5-HT)/Postpartum depression分类
医药卫生引用本文复制引用
陈静,夏光源,汤稳权,魏华,邹涛..产后抑郁与分娩前后孕酮、雌二醇变化的相关性研究[J].四川精神卫生,2014,(5):385-389,5.基金项目
贵州省科学技术基金(【2009】2323)。 （【2009】2323）
