摘要
Abstract
Objective To explore the effect of olanzapine and risperidone on thyroid functions of schizophrenic patients. Methods 54 patients with schizophrenia who conform to CCMD-3 were randomly divided into two groups according to the random number table. The risperidone group 29 cases,the initial dose of 4 mg/d,2 weeks gradually increased to 6 mg/d,the observation to 8 weekends;olanzapine group 25 cases,the initial dose of 10 mg/d,2 week and gradually increased to 15mg/d,the observation to eight weekends. The patients in the two groups had no differences in age,sex,culture degree(P﹥0. 05). Respectively,test three measuring serum triiodothyronine( TT3 ),thyroxine( TT4 ),free three triiodothyronine( FT3 ),free thyroxine( FT4 )and thyroid stim-ulating hormone( TSH)level before treatment and eighth weekend. Results With the treatment of risperidone,TT3 ,TT4 ,FT3 ,FT4 , thyroid stimulating hormone( TSH)levels were increased,but the difference was not statistically significant,compared with the normal group,the increase of TT3 had statistical significance;the levels of TT3 ,TT4 ,FT3 ,FT4 were decreased after treatment with olanzap-ine,FT3 and FT4 decreased significantly before and after treatment[(3. 01 ± 0. 28)vs.(2. 81 ± 0. 26),(0. 91 ± 0. 2)vs.(0. 77 ± 0. 14),P﹤0. 05]. TSH increased,but without statistical significance. TT3 ,FT3 levels increased significantly after treatment with ris-peridone group,there is statistical significance compared with olanzapine group(P﹤0. 05). Conclusion Risperidone has no signifi-cant effect on patientˊs thyroid hormones. Olanzapine can affect patients with schizophrenia FT3 ,FT4 level,should pay attention to the monitoring using olanzapine in the treatment of thyroid function in patients with schizophrenia.关键词
精神分裂症/非典型抗精神病药/甲状腺激素/利培酮/奥氮平Key words
Schizophrenic/Atypical antipsychotic drugs/Thyroid hormones/Olanzapine/Risperidone分类
医药卫生
