摘要
Abstract
Objective To explore the influence of repetitive transcranial magnetic stimulation( rTMS)combined sertraline on the curative effect and cognitive function of post-schizophrenia depression patients. Methods 78 cases of post-schizophrenia depression patients conform to the International Classification of Diseases,tenth edition(ICD-10)were randomized divided into observation group (39 cases)and control group(39 cases),The control group treated with sertraline,patients were given rTMS treatment in observation group on the basis of control group. Two groups of patients were assessed by using Hamilton Rating Scale for Depression( HRSD),The Herth hope index scale(HHI)and Wisconsin card sorting test(WCST)to evaluate before and after 6 weeks treatment. Results The scores of the HRSD in the two patients was significantly lower than before after 6 weeks treatment(t=34. 212,P﹤0. 01). The scores of HRSD in the observation group were significantly lower than those in the control group(t=6. 705,P﹤0. 01). The scores of the HHI total score and each factor score in the two groups were higher than before treatment(t=3. 184,2. 799,4. 265,2. 855,P﹤0. 01). The scores of HHI in the observation group were significantly higher than those in the control group( t=3. 184,2. 799,4. 265,2. 855,P﹤0. 01). The WCST scores of the observation group is improved than before(t=20. 399,18. 558,5. 101,5. 894,15. 385,P﹤0. 01). Compered with the control group,the WCST scores of the observation group is improved,the difference was statistically significant( t=11. 900,10. 614,3. 739,3. 573,6. 229,P﹤0. 01). Conclusion rTMS combined with sertraline can improve the efficacy,the level of the hope and cognitive function in post-schizophrenia depression.关键词
精神分裂症后抑郁/重复经颅磁刺激/心理希望/认知功能Key words
Post-schizophrenia depression/Repetitive transcranial magnetic stimulate/Level of the hope/Cognitive function分类
医药卫生
