四川精神卫生Issue(1)：51-53,3.DOI:10.11886/j.issn.1007-3256.2015.01.017
精神分裂症患者血清甲状腺激素水平及其治疗前后变化和相关因素分析
Serum thyroid hormone levels of schizophrenia patients and changes before and after treatment and the analysis of realted factors
李田妹 1李晓琴 1颜成裕 2柯峥 1许锦泉 1陈玲 1冼怀柏1
作者信息
- 1. 524012 广东省湛江市第三人民医院
- 2. 湛江市计划生育服务中心
- 折叠
摘要
Abstract
Objective To investigate changes in thyroid hormone levels and related factors in patients with schizophrenia before and after treatment. Methods Select the first or recurrent hospitalization nearly a year of unused medication inpatients with schizo-phrenia80 cases. The use of chemical luminescence method at the time of immunization into the group,after eight weeks of treatment serum thyroid hormone levels,comparing before and after the change,and 50 healthy controls and apply the same detection method de-tection results compared. Research Group at the time of enrollment,eight weeks of treatment scale assessment of positive symptoms (SAPS),Negative Syndrome Scale(SANS)and the side effects scale(TESS). Results TT4 before and after treatment were(5. 99 ± 1. 33)and(6. 53 ± 2. 10),FT3 were(2. 75 ± 0. 83)and(2. 81 ± 0. 79),and the control group TT4(6. 78 ± 1. 91),FT3(3. 30 ± 1. 05)statistical comparison significance(P<0. 05). TSH before treatment were(1. 04 ± 0. 60)after the treatment(1. 27 ± 0. 43) and control group(1.23 ±0.51)was statistically significant comparison(P<0. 01). TSH value of(1. 17 ± 0. 37)and(1. 52 ± 0. 48)comparing before and after the treatment of negative symptoms group was statistically significant(P<0. 05),after treatment with the control group(1. 23 ± 0. 51)was statistically significant comparison(P<0. 05). Conclusion There are some anomalies in patients with schizophrenia in the HPT axis functions to TT4 ,FT3 and TSH decrease mainly. Antipsychotic drugs may affect thyroid hormone levels,but no specific changes in thyroid hormone levels and clinical symptoms,and other aspects of efficacy and side effects were not correlated.关键词
甲状腺激素/SAPS/SANS/TESS/HPT轴Key words
Thyroid hormone/SAPS/SANS/TESS/HPT axis分类
医药卫生引用本文复制引用
李田妹,李晓琴,颜成裕,柯峥,许锦泉,陈玲,冼怀柏..精神分裂症患者血清甲状腺激素水平及其治疗前后变化和相关因素分析[J].四川精神卫生,2015,(1):51-53,3.
