四川精神卫生Issue(2)：138-140,141,4.DOI:10.11886/j.issn.1007-3256.2015.02.013
逍遥丸治疗利培酮所致女性精神分裂症患者高泌乳素血症的临床研究
Clinical study of Xiaoyao Pill on hyperprolactinemia caused by risperidone in the female schizophrenics
摘要
Abstract
Objective To study the clinical effect of Xiaoyao Pill on hyperprolactinemia caused by risperidone in the female schizophrenics. Methods All of 72 female with Hyperprolactinemia(serum PRL ﹥ 25ng/ ml)caused by risperidone were divided into the study group and the control group by random number table method,36 cases of each group. And all of the participants met the cri-terion of Diagnostic and Statistical Manual of Mental Disorders Fourth edition(DSM - IV). The study group was used Xiaoyao Pill,and the control group was the pill made by the flour for 6 months. The treatment effects of two groups were compared by the changes of men-struate and the level of PRL. The treatment effects of the symptoms of psychosis were evaluated by PANSS and CGIS before and at the end of 1st ,2nd ,6th month of treatment respectively. The adverse drug reactions were assessed by TESS. Results ①Compared with the control group,the levels of PRL of the study group were declined and the treatment effects were better at the 2nd month and the end of the 6th month,the differences were statistical significant(P < 0. 05). Moreover,the factor of time significantly effected on the level of PRL and the clinical efficacy(P < 0. 05). ②The scores of PANSS and CGIS were higher than pre - treatment at the end of the 2nd and the 6th month,the differences were statistical significant(P <0. 05). But the difference between two groups had no significant dif-ferent(P ﹥0. 05). ③The occurrence of adverse drug reactions of the two groups had no significant different in pre - treatment and post -treatment(P ﹥0. 05). Conclusion Xiaoyao Pill has effect on hyperprolactinemia caused by risperidone in the female schizophrenics. Furthermore,Xiaoyao Pill doesn’t effect on the symptoms of psychosis,and it doesn’t cause any adverse drug reactions.关键词
逍遥丸/利培酮/女性精神分裂症患者/高泌乳素血症Key words
Xiaoyao Pill/Risperidone/The female schizophrenics/Hyperprolactinemia分类
医药卫生引用本文复制引用
刘芙蓉,周平,李祎鋆,郑婵燕..逍遥丸治疗利培酮所致女性精神分裂症患者高泌乳素血症的临床研究[J].四川精神卫生,2015,(2):138-140,141,4.基金项目
广东省中医药局基金项目 （）
