摘要
Abstract
Objective To study on the treatment effects of amisulpiride on different subtypes of schizophrenia. Methods Totally 150 cases of first - episode schizophrenic inpatients who met criteria for schizophrenia as defined by the Chinese Classification of Mental Disorders - third edition(CCMD - 3)were grouped according to clinical subtype and positive and negative symptoms types. All of them were treated with appropriate dose amisulpiride 200mg/ d on the first day,and the next day 300mg/ d,300 ~ 400mg/ d third day, fifth day,according to the illness and felt after adjusting the dose of medication to 400 ~ 1000mg/ d,divided into 2 doses,They were treated based on the principles of clinical medicine and illness conditions for 8 weeks. The Positive and Negative Syndrome Scale (PANSS)was tested before treatment and 1,4,and 8 weeks after treatment. The curative effects of 8 weeksˊtreatment were evualuated according to four levels of clinical efficacy criteria. The differences of PANSS total score deduction rate,dosage and curative effects were compared among different subtypes. Results After 4 and 8 weeks of treatment,PANSS total scores of different subtypes were significantly lower than those before treatment(P < 0. 01). In first week of treatment,the total scores of PANSS in paranoid,undifferen-tiated,hebephrenic type and type I showed significantly lower than those before treatment(P < 0. 05 or 0. 01). PANSS total score de-duction rates of 1,4,8 weeksˊ treatment showed higher in paranoid type group than in catatonic type group,and in type I than in type II group. The differences were statistically significant(P < 0. 01). The differences of efficacy and curation rates of 8 weeksˊtreatment were not statistically significant among different subtypes(P ﹥ 0. 05). But,the average doses of amisulpiride in paranoid type and type I were markedly higher,the differences were statistically significant(P < 0. 01). Conclusion Amisulpiride has better effects on the sub-types of schizophrenia patients. Itˊs important to adjust adjust individual therapeutic doses according to subtypesˊ characteristics.关键词
精神分裂症/临床亚型/氨磺必利/疗效Key words
Schizophrenia/Clinical subtype/Amisulpiride/Efficacy分类
医药卫生
