四川医学Issue(6)：660-662,3.
硝普钠控制性降压辅以右美托咪定在脊柱手术中的运用
Application of Sodium Nitroprusside Combined with Dexmedetomidine for Controlled Hypotension in Spinal Opera-tion
罗方毅 1庞波 1刘雪茹2
作者信息
- 1. 乐山市人民医院麻醉科，四川 乐山614000
- 2. 泸州医学院附属医院麻醉科，四川 泸州646000
- 折叠
摘要
Abstract
Objective To evaluate the application of dexmedetomidine ( DEX) in controlled hypotension with sodium nitro-prusside ( SNP) and take the basis for clinical application. Methods 120 patients who underwent spinal operation with ASA I-II were divided 2 groups ( n=60 each group) randomly:A, SNP group;B, SNP and DEX group. There was no significant difference between two groups in common information such as sex and age. HR and MAP were recorded in before operation ( T0 ) , controlled hypotension for 5 min (T1), stopped hypotension for 5 min (T2) and after extubation for 1 min (T3) each group. The duration of hypotension and extubation after operation was also recorded. Results HR in group B was slower than that in group A in T1, T2, T3 (P<0. 05 or P<0. 01). MAP in group B was lower in T2 and T3. there was no significant difference between two groups in du-ration of hypotension and extubation after operation. The dose of SNP in group B was decreased from 34. 62 ± 6. 39 mg to 27. 58 ± 5. 86 mg (P<0. 05). Conclusion It may maintain reasonable MAP and HR, and decreased the dose of SNP that DEX was applied in control hypotension with SNP. DEX is a good candidate for ancillary drug in control hypotension with reducing the adverse effect of SNP.关键词
控制性降压/硝普钠/右美托咪定/脊柱手术Key words
controlled hypotension/sodium nitroprusside/dexmedetomidine/spinal operation分类
医药卫生引用本文复制引用
罗方毅,庞波,刘雪茹..硝普钠控制性降压辅以右美托咪定在脊柱手术中的运用[J].四川医学,2014,(6):660-662,3.
