四川医学Issue(7)：757-760,4.
脓毒症患者肾损伤程度与血浆血管生成素-1、2水平相关性的研究
Relationship between the Severity of Kidney Damage and the Levels of Ang-1 and Ang-2 in Patient with Sepsis
摘要
Abstract
Objective To investigate the relationship between the severity of kidney damage and the level of Ang-1 and Ang-2 in patients with sepsis. Methods 96 septic patients admitted to ICU were divided into NAKI group (n = 46),AKIⅠgroup (n = 23),AKIⅡ group (n = 11),AKIⅢ group (n = 16) according to different damage degrees under AKIN criteria, and 30 healthy people were also enrolled as healthy control group(n = 30). The clinical data including the acute physiology and chronic healthy conditions(APACHE) Ⅱ score and sequential organ failure(SOFA) score were collected and recorded. Blood samples were collected to detect plasma Ang-1,Ang-2 , Scr and Ccr and correlation was analyzed. Results ①The plasma Ang-1 levels in NAKI, AKIⅠ, AKIⅡ, AKIⅢ groups were significantly lower compared with CON group (P < 0. 01), but there were no differ-ence among the four groups (P > 0. 05). The plasma Ang-2 levels in NAKI, AKIⅠ,AKIⅡ,AKIⅢ groups were significantly higher compared with CON group (P < 0. 01), and the plasma Ang-2 levels of the four groups significantly increased as their AKI classification increased. ②The plasma Ang-1 level and Ccr was not correlated (P > 0. 05). The plasma Ang-2 level and Ccr was significant correlated (P < 0. 01). Multiple linear regression analysis showed that plasma Ang-2 level was significantly independ-ently correlated with Ccr (P < 0. 01). ③The plasma Ang-1 levels and the APACHEⅡ score and SOFA score were not correlated (P > 0. 05). The plasma Ang-2 levels and the APACHEⅡ score and SOFA score was positively correlated (P < 0. 01). Multiple linear regression analysis showed that plasma Ang-2 level was significantly independently correlated with the APACHEⅡ score and SOFA score (P < 0. 05). Conclusion The plasma Ang-2 level is an independent risk factor associated with severity of kidney damage of septic patients.关键词
血管生成素-1/血管生成素-2/脓毒症/急性肾损伤Key words
Angiopoietin-1/Angiopoietin-2/sepsis/acute kidney injury分类
医药卫生引用本文复制引用
麦振华,佟琳,钟秀明,邓烈华,姚华国,张媛莉..脓毒症患者肾损伤程度与血浆血管生成素-1、2水平相关性的研究[J].四川医学,2014,(7):757-760,4.基金项目
广东省医学科研基金(编号:A2009484) （编号:A2009484）
湛江市科技攻关计划项目(编号:2013B01038) （编号:2013B01038）
广东医学院科研基金(编号:M2013028) （编号:M2013028）
