四川医学Issue(8)：929-931,3.
MRAS基因与中国汉族人群动脉粥样硬化性脑梗死相关性研究
The MRAS Genetic Variation is Associated with Atherothrombotic Stroke in Han Chinese Population
摘要
Abstract
Objective To evaluate whether the single nucleotide polymorphisms( SNPs) of the MRAS( muscle RAS onco-gene homolog gene) gene are associated with increased risk of Atherothrombotic Stroke( ATS) in Han Chinese population. Methods A case-control association study, including only ATS( a major subtype in Korean modified TOAST classification) , was conduc-ted. Subgroup analyses were also carried out to determine whether the effect of the MRAS polymorphism is specific to age and gen-der in participants. Results 194 ATS cases and 186 controls were included in the present study. A multivariate regression analy-sis showed positive association of rs40593 with ATS under dominant and additive models after adjustment for covariates. Sub-group analyses revealed that the AG genotype for rs40593(P=0. 028), CT genotype for rs3755751(P=0. 036)or G-allele carriers(AG plus GG)for rs40593(P=0. 015)had a significant protective effect in the group of 45 years and older. Conclusion The data sug-gest a positive association of the MRAS gene with ATS in the Han Chinese population.关键词
缺血性脑卒中/动脉粥样硬化性脑卒中/单核苷酸多态性/基因变异Key words
ischemic stroke/atherothrombotic stroke/single neucleotide/polymorphism/genetic variation分类
医药卫生引用本文复制引用
杜鑫,邱亚,柳华,刘伟,熊利..MRAS基因与中国汉族人群动脉粥样硬化性脑梗死相关性研究[J].四川医学,2014,(8):929-931,3.基金项目
四川省卫生厅基金项目(编号:100332) （编号:100332）
南充市科技局基金项目(编号:2010SF16) （编号:2010SF16）
