四川医学Issue(8)：935-936,937,3.
高氧诱导A549细胞凋亡
Apoptosis of A549 Cells Induced by Hyperoxia
摘要
Abstract
Objective To explore the mechanism of apoptosis of A549 cells induced by hyperoxia. Methods A549 cell was used as target cell. The cultural cells in orifice were divided into control group and hyperoxia group. The cells of control group were cultivated with normal condition, and the cells of hyperoxia group were attacked by hyperoxia exposure. After 48 hours, Cell viability was determined by MTT assay, the apoptosis rate and caspase-8 expression of the cells in the two groups were detected re-spectively. Results As compared with control group, after exposed to hyperoxia for 48 hours, cell viability was decreased, the rate of apoptosis and caspase-8 expression were increased significantly. Conclusion Hyperoxia could enhance the apoptosis of A549 cells by upregulating the expression of caspase-8.关键词
高氧/细胞活力/凋亡/caspaseKey words
hyperoxia/cell viability/apoptosis/caspase分类
医药卫生引用本文复制引用
张勇,廖志,叶飘,韩彦青,石境懿,罗红权..高氧诱导A549细胞凋亡[J].四川医学,2014,(8):935-936,937,3.基金项目
四川省卫生厅科研基金资助项目(编号:100411) （编号:100411）
