四川医学Issue(8)：966-969,4.
CD44 v6和Galectin-3在宫颈癌中的表达及临床意义
Expressions and Clinical Significances of CD44v6 and Galectin-3 in Cervical Carcinoma
吴和刚 1任玲淑 1张续 1李天永 1周开梅 1袁森辅 1郭宇 1董华菊1
作者信息
- 1. 宜宾市第一人民医院病理科，四川 宜宾644000
- 折叠
摘要
Abstract
Objective To evaluate the expression of CD44v6 and Galectin-3 in cervical carcinoma and its clinical significance. Methods Ex-pression level of CD44v6 and Galectin-3 proteins in cervical carcinoma were detected by immunohistochemical method in 25 normal cervix, 45cases CIN and 83cases cervical carcinoma, and analyzed the relation with clinical pathologic parameters. Results ①The positive expression rate of CD44v6 and Galectin-3 was 77. 11%, 81. 93%, which was higher than that in CIN and normal cervix(P<0. 05). ②NF-κBp65 expression was significant correla-tion with the degree of histological grade and lymph node metastasis(P<0. 05), but there was not obviously correlated with other clinical pathological parameters(P>0.05). ③CD44v6 expression was positive correlated with Galectin-3(r =0.415, P =0.000). Conclusion The expression of CD44v6 and Galectin-3 protein were associated with the development and metastasis of cervical cancer. The combined detection of CD44v6 and Galec-tin-3 proteins can be used to provide an important basis for judge prognosis of cervical cancer.关键词
CD44v6/Galectin-3/宫颈癌Key words
CD44v6/Galectin-3/carcinoma of the uterine cervix分类
医药卫生引用本文复制引用
吴和刚,任玲淑,张续,李天永,周开梅,袁森辅,郭宇,董华菊..CD44 v6和Galectin-3在宫颈癌中的表达及临床意义[J].四川医学,2014,(8):966-969,4.
