四川医学Issue(9)：1113-1115,3.
糖皮质激素短期干预对AECOPD患者清晨空腹皮质醇的影响
Influences of the Short-Term treatment With Glucocorticoid on Morning Basal Cortisol Levels in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To explore the effects of the short-term therapy with glucocorticoid on morning basal cortisol levels in patients with acute exacerbation chronic obstructive pulmonary disease( AECOPD) . Methods 38 patients with AECOPD were randomly divided into glucocorticoid group and control group, of which each got 19 patients for this study . The levels of basal cor-tisol levels in serum were tested and compared by radioimmunoassay before and after the treatment. Results There were no signif-icant differences between two groups in cortisol,so these two groups were comparable. Serum cortisol were reduced in both groups after treatment,However, there were no statistically significant differences between the glucocorticoid group and the control group in basal cortisol(P>0. 05). Conclusion The short-term treatment with glucocorticoid had no significant differences on the serum level of basal cortisol between the glucocorticoid group and the control group. The study suggests that short-term treatment with glu-cocorticoid had no effects on hypothalamic pituitary adrenalcortex( HPA) , so it is safe in the treatment of AECOPD.关键词
糖皮质激素/慢性阻塞性肺疾病急性加重期/空腹皮质醇Key words
glucocorticoid/acute exacerbation chronic obstructive pulmonary disease/serum morning basal cortisol分类
医药卫生引用本文复制引用
刘霞,田景伦,闫芳..糖皮质激素短期干预对AECOPD患者清晨空腹皮质醇的影响[J].四川医学,2014,(9):1113-1115,3.基金项目
四川省卫生厅科研课题(编号:060203) （编号:060203）
