四川医学Issue(12)：1535-1538,4.
产前诊断21-三体胎儿和出生后检出21-三体综合征的临床相关分析
Clinical Relevance Analysis of Prenatal Diagnosis of 21-trisome Fetus and Postnatal Detection of 21-trisome Syn-drome Patients
秦胜芳 1伍志灵 1邓艺 1李运星 1陈春 2魏萍 1曾兰 1汪雪雁 1席娜 1唐书琴 1叶梦玲1
作者信息
- 1. 四川省妇幼保健院·四川省产前诊断中心，四川 成都 610045
- 2. 成都中医药大学第二临床医学院，四川 成都 610045
- 折叠
摘要
Abstract
Objective To observe the elementary validity of the prenatal screening and diagnosis in reducing the birth rate of 21-trisome syndrome fetuses after diagnosis of the 21-trisome in clinic. Methods In prenatal diagnosis,chromosome karyo-type of amniotic fluid cell or cord blood cell was analyzed after culturing and G-banding,and FISH technology to detect uncultured cell of amniotic fluid in 6059 pregnant women;In the detection of postnatal patients,peripheral blood chromosome karyotype was analyzed after culturing and G-banding in 174 patients who suffered from mental retardation or body growth slowly or malformation, and carried out follow-up investigation retrospectively. Results 49 cases of 21-trisome fetuses were diagnosed in the prenatal diag-nosis pregnant women,and 48 cases of 21-trisome syndromes were detected in peripheral blood in the five past years. Conclusion Comprehensive measures play a very important role in reducing the birth rate of the 21-trisome syndrome. The work of prenatal screening and prenatal diagnosis is still to strengthen in Sichuan Province.关键词
产前筛查/产前诊断/21-三体综合征Key words
prenatal screening/prenatal diagnosis/21-trisome syndrome分类
医药卫生引用本文复制引用
秦胜芳,伍志灵,邓艺,李运星,陈春,魏萍,曾兰,汪雪雁,席娜,唐书琴,叶梦玲..产前诊断21-三体胎儿和出生后检出21-三体综合征的临床相关分析[J].四川医学,2014,(12):1535-1538,4.
