四川医学Issue(1)：28-31,4.DOI:10.16252/j.cnki.issn1004-0501-2015.01.009
C型利钠肽扩张猪冠状动脉的作用及机制的研究
The Effects and Mechanism of C-Type Natriuretic Peptides on Swine Heart Coronary Artery
舒燕 1李其勇 1姜荣建 1孔洪1
作者信息
- 1. 四川省人民医院心内科，四川 成都610072
- 折叠
摘要
Abstract
Objective Investigate the influences of C-natriuretic peptides on langendorff-perfused swine heart coronary. Reveal the underlying vasodilatory ability and mechanism of C-natriuretic peptides. Methods Three different groups named the C-Natriuretic Group ( CNP Group) , the Nitroglycerol Group ( GTN Group) , and the NPR-C Receptor Agonist Group ( cANF4-23 Group) were set up.①Each of above groups was perfused by solution of NE,and then was perfused by GTN、CNP and cANF4-23. The vasodilatory influences of CNP and GTN on swine heart coronary arteries and whether cANF4-23 were involved in this procedure were studied .②cANF4-28 was given first, and then CNP were added, the vasodilatory influences were observed.③K + solutions ( at the concentration of 80 nM) were used to preserve the arteries, so they were all in contracted state, and then CNP and cANF4-23 were added, and the vasodilatory influences were observed. Results ①CNP,GTN and cANF4-23 all had significant vasodilatory in-fluences on swine heart coronary artery. no significant difference of vasodilation influences was found between CNP Group and cANF4-23 Group(P>0. 05). The vasodilatory influence of CNP Group was weaker than GTN Group (P<0. 05).②In cANF4-28 preserved arteries, The largest circulus vasculosus vasodilatory ratios of CNP was significantly weaker than Control Group , and had statistical significance (P<0. 01).③The vasodilatory influences of CNP and cANF4-23 Groups were significantly decreased in high concentration K + solution in contrast with the Control Group ( P<0. 05 ) , but not blocked. Conclusions C- Natriuretic peptides have significant vasodilatory influence on swine heart coronary artery. The vasodilatory mechanism of CNP involves NPR-C. NPR-C is not only the well-known clearance receptor, but also leads to vasodilation of the coronary artery. the vasodilatory of CNP/NPR-C sig-naling involves K+ channel.关键词
C型利钠肽/受体/钾通道/冠状动脉Key words
C-natriuretic peptides/receptor/K + channel/coronary artery分类
医药卫生引用本文复制引用
舒燕,李其勇,姜荣建,孔洪..C型利钠肽扩张猪冠状动脉的作用及机制的研究[J].四川医学,2015,(1):28-31,4.
