四川医学Issue(1)：35-37,38,4.DOI:10.16252/j.cnki.issn1004-0501-2015.01.011
GP方案引起NSCLC患者糖耐量异常的临床研究
Clinical Study of Glucose Levels in Patients with Advanced Non-small Cell Lung Cancer Treated by GP Regimen
摘要
Abstract
Objective To evaluate blood glucose differences before and after three cycles of chemotherapy in patients with advanced non-small cell lung cancer. Methods 44 patients with advanced non-small cell lung cancer conducted blood routine,bi-ochemical,and C-reactive protein test;Normal blood glucose group treated chemotherapy with GP 3 cycles,high blood sugar groups measured blood glucose by oral glucose tolerance test,then were on diets,exercised or injected insulin. After GP regimen of 3 cy-cles,blood analysis,biochemical,C-reactive protein,oral glucose tolerance test,c-peptide and insulin release test were measured. Results After 3 cycles of GP,25%(8/32) of patients with normal glucose appears abnormal,and half of patients with abnormal glucose tolerance turn into diabetic. After chemotherapy,aspartate aminotransferase and C-reactive protein were significantly differ-ent from the patients with increased blood glucose and normal blodd glucose,the difference was statistically significant(P<0. 05). Conclusion GP regimen could cause glucose metabolism disorders in some patients with advanced non-small cell lung cancer and even induce diabetes. Patients with abnormal aspartate aminotransferase and C-reactive protein are susceptible to elevate blood glu-cose.关键词
非小细胞肺癌/化疗/糖尿病Key words
non-small cell lung cancer/chemotherapy/diabetes mellitus分类
医药卫生引用本文复制引用
姚兰,蒋成霞,徐勇,叶序卷,贾钰铭,雷开键,唐元英..GP方案引起NSCLC患者糖耐量异常的临床研究[J].四川医学,2015,(1):35-37,38,4.基金项目
宜宾市“一抓一”科技工程项目(编号:2012 ZSF007) （编号:2012 ZSF007）
