四川医学2015，Vol.36Issue(5)：665-668,4.DOI:10.16252/j.cnki.issn1004-0501-2015.05.024
人重组促红细胞生成素联合铁剂治疗慢性心力衰竭合并贫血患者187例疗效观察
Clinical Research of Erythropoietin and Ferrous Object in 187 Patients of Chronic Congestive Heart Failure with A-
nemia
姜小飞 1叶芬 1陈曦 1石理1
作者信息
- 1. 暨南大学附属珠海医院·珠海市人民医院心内科,广东 珠海519000
- 折叠
摘要
Abstract
Objective To explore the applied effectiveness of Erythropoietin( EPO) in Chronic Congestive Heart Failure ( CHF) with anemia. Methods 187 patients CHF with anemia were divided at random into three groups: Ferrous group (62cases),EPO group(62cases),Combine group(63cases).Ferrous were given to the ferrous group;EPO were given to the EPO group. EPO and ferrous were given to the treatment group,and the duration of therapy was 6 months. Hemoglobin,B-type natriuretic peptide(BNP),left ventricle ejection fraction(LVEF),diameter of diastolic left ventricle(LVDd),6 minute walking distance (6-MWD),heart function(NYHA functional class)were measured before and after therapy immediately and 12 months later. Re-sults After therapy for six months and follow up for 12 months, the level of Hemoglobin, LVEF and 6-MWD were increased, and BNP,NYHA functional class and LVDd were significant decreased after the therapy in all the groups(all P＜0. 05). All the inde-xes of Combine group were significant changed compared to other two groups(P＜0. 05). Conclusion On basis of regular treat-ment of anti heart failure, intervention with EPO and ferrous against anemia could decrease the level of BNP and improve heart function of CHF with anemia.关键词
充血性心力衰竭/贫血/促红细胞生长素/铁剂Key words
congestive heart failure/anemia/erythropoietin/ferrous分类
医药卫生引用本文复制引用
姜小飞,叶芬,陈曦,石理..人重组促红细胞生成素联合铁剂治疗慢性心力衰竭合并贫血患者187例疗效观察[J].四川医学,2015,36(5):665-668,4.
