摘要
Abstract
Objective To analyze the treatment response of chronic obstructive pulmonary disease ( COPD) patients with different phenotypes useing long-term β2 agonists and inhaled corticosteroids. Methods Patients with stable COPD by using the salmeterol and fluticasone hospitalized in the department of respiration of our hospital were enrdled. The patients was defined as emphysema type COPD according to the results of HRCT with low attenuation area percentage( LAA%) over 15%,another was chronic bronchitis type COPD. Patients were accepted pulmonary function test, routine examination, modified British Medical Re-search Council Dyspnea Scale(MMRC) were used to assessment dyspnea degree,and using the St. George’s Respiratory Question-naire( SGRQ) by patients self-assessment breathing problems. Result 297 COPD patients in stable phase were enrolld. Comparied of mean age,sex ratio between chronic bronchitis and emphysema type COPD patients,showed no statistically significant(P>0. 05), excepst BMI (P<0. 05). MMRC and SGRQ between two groups have no significant difference(P>0. 05)before streatment,and FEV1pre,FEV1/FVC,ICpre,RVpre had statistically significant(P<0. 05). The difference of ΔFEV1、ΔRV bteween two groups af-ter 12 weeks of treatment,was statistically significant(P<0. 05),but ΔTLC、ΔIC statistically significant(P>0. 05). Conclusion①The treatment response of chronic obstructive pulmonary disease ( COPD ) patients with different phenotypes respectively using long-term β2 agonists and inhaled corticosteroids had significant differences.②Emphysema type COPD patients had higher grade, decreased faster FEV 1 ,more poor response to treatment.关键词
肺气肿型/慢性支气管炎型/慢性阻塞性肺疾病/治疗应答性Key words
emphysema/chronic bronchitis/chronic obstructive pulmonary disease/treatment response分类
医药卫生
