中国伤残医学Issue(3)：23-25,3.DOI:10.13214/j.cnki.cjotadm.2015.03.015
缺氧诱导因子HIF－1a和Endoglin在子痫前期患者胎盘中的表达及其与母体血清sEng的相关性研究
Relationship of Hypoxia-inducible Factor-1αand Endoglin Expression in Placenta and Soluble Endoglin in Serum in Preeclampsia
何美荣 1舒竞铖 1黄星 1尹时华1
作者信息
- 1. 广西壮族自治区广西医科大学第一附属医院，广西南宁 530021
- 折叠
摘要
Abstract
Objective:To detect the expression of hypoxia -inducible factor-1a and Endoglin in placenta and soluble Endoglin in ser-um of preeclampsia , explore the role of them in pathogenesis of preeclampsia .Methods:35 patients with preeclampsia ( preeclampsia group) and 40 healthy pregnant women ( control group ) were selected in the same period , the level of serum seng was detected by enzyme linked Immunosorbent assay .The expression of hypoxia -inducible factor -1a and endoglin in placenta were detected by immunohisto-chemistry.Results:The levels of serum sEng in mild preeclampsia group was significantly higher than that in control group (P<0.05), and was significantly higher in severe preeclampsia group than that in mild preeclampsia group (P<0.05).The expression of hypoxia -inducible factor-1αand Endoglin protein in placenta of mild preeclampsia group were significantly than those in control group ( P<0. 05), and was significantly higher in severe preeclampsia group than those in mild preeclampsia group (P<0.05).Positively correlation a-mong HIF-1a、Endoglin and sEng were found in study groups ( r=0.859,0.895), respectively.Conclusion:the high expression of HIF-1a、Endoglin and sEng with positively correlation in preeclampsia group , indicate they may common participant in the Pathophysiologic process of preeclampsia .关键词
子痫前期/缺氧诱导因子/内皮因子/可溶性内皮因子/胎盘Key words
Preeclampsia/Hypoxia-inducible/Factor-1a/Endoglin/Placenta分类
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何美荣,舒竞铖,黄星,尹时华..缺氧诱导因子HIF－1a和Endoglin在子痫前期患者胎盘中的表达及其与母体血清sEng的相关性研究[J].中国伤残医学,2015,(3):23-25,3.
