中国伤残医学Issue(4)：19-21,22,4.DOI:10.13214/j.cnki.cjotadm.2015.04.015
GPx-3基因与高血压并缺血性脑卒中的关联性及其与环境因素的交互作用
Association of GPx-3 and its interaction with environmental factors for hypertension concomitant ischemic strok
郝瑩 1吴宝刚 2刘宇翔 1邵丽匀1
作者信息
- 1. 辽宁省金秋医院心内科，辽宁 沈阳 110015
- 2. 中国医科大学附属盛京医院老年病科
- 折叠
摘要
Abstract
Objevtive:To analyze the association of GPx-3 and its interaction with environmental factors for hypertension concomitant ischemic stroke. Methods:At Fuxin rural areas, Han people who lived there from ancestor were selected as participation. 238 unrelated hypertensives and 75 hypertensives concomitant ischemic stroke were recruited. We genotyped rs3828599 of GPx-3 with pyrosequencing ( PSQ) . The logistic regression model was used to test the association between rs3828599 and hypertension concomitant ischemic stroke. We evaluated interaction between rs3828599 and risk variant carrier status for hypertension concomitant ischemic stroke with multifactor dimensionality reduction ( MDR) software. Results:1. Under recessive, dominant and codominant genetic model, three genotypes of rs3828599 did not significantly increase the risk of hypertension concomitant ischemic stroke ( P>0. 05) ,neither before nor after adjus-ted confounding factors. 2. Male, drinking status, total cholesterol (TC) and triglyceride (TG) had interaction with rs3828599 for hyper-tension concomitant ischemic stroke. Conclusion:GPx-3, male, drinking, TG and TC synergistically participate the pathogenesis of hy-pertension concomitant ischemic stroke, however, the polymorphism of rs3828599 of GPx-3 gene might not be the main risk factor for hy-pertension concomitant ischemic stroke in rural Han Chinese in Fuxin, Liaoning.关键词
高血压/缺血性脑卒中/GPx-3/关联性/交互作用Key words
Hypertension/Ischemic Stroke/GPx-3/Association/Interaction分类
医药卫生引用本文复制引用
郝瑩,吴宝刚,刘宇翔,邵丽匀..GPx-3基因与高血压并缺血性脑卒中的关联性及其与环境因素的交互作用[J].中国伤残医学,2015,(4):19-21,22,4.
