肿瘤预防与治疗Issue(4)：171-175,5.DOI:10.3969/j.issn.1674-0904.2014.04.003
四川省女性ERα基因多态性与乳腺癌风险关系的病例对照研究
ERαGene Polymorphism and Breast Cancer Risk among Females in Sichuan Province：A Case-control Study
曹兰青 1李卉 2刘莉 1王琼 3李冬锋 3齐亚娜 3李佳圆3
作者信息
- 1. 成都市妇女儿童中心医院，成都610041
- 2. 四川省肿瘤医院，成都610041
- 3. 四川大学华西公共卫生学院，流行病与卫生统计学系，成都610041
- 折叠
摘要
Abstract
Objective: To explore the association between XbaⅠand PvuⅡgene polymorphism of ERαand breast cancer risk among females in Sichuan province. Methods: A case-control study was designed. A total of 221 cases of breast cancer and 252 controls were sequentially collected. Questionnaires were used to obtain the factors including demo-graphic characteristics, height, weight, history of reproduction, and estrogen taking history. Restricted fragment length pol-ymorphisms were used to examine XbaⅠ(rs9340799) A/G (x/X), PvuⅡ(rs2234693) C/T (P/p) of ERα. Uncondi-tional logistic regression model was used to evaluate the single and combined effects of XbaⅠ, PvuⅡ gene polymorphism on breast cancer risk. Subgroup analysis on menopausal status was also performed. Results: Significantly association be-tween XbaⅠ, PvuⅡ gene polymorphism and breast cancer was observed among neither total group nor subgroups ( P>0. 05). Conferring to xxPP genotype carriers, for general females, carrying X mutate alleles had lower breast cancer risk (OR=0. 31,95%CI:0. 11-0. 90),which was closed to the effect of co-exposure of X and p allele (OR=0. 39,95%CI:0. 15-1. 00). In premenopausal women, the effect of the exposure modalities above were 0. 12(0. 03-0. 54)and 0. 25 (0. 07-0. 89) respectively. Conclusions:Carrying X allele of XbaⅠmay decrease the risk of breast cancer.关键词
乳腺肿瘤/雌激素受体α/多态性,单核苷酸Key words
Breast Neoplasms/Estrogen Receptor Alpha/Polymorphism/Single Nucleotide分类
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曹兰青,李卉,刘莉,王琼,李冬锋,齐亚娜,李佳圆..四川省女性ERα基因多态性与乳腺癌风险关系的病例对照研究[J].肿瘤预防与治疗,2014,(4):171-175,5.
