肿瘤预防与治疗Issue(6)：259-263,5.DOI:10.3969/j.issn.1674-0904.2014.06.001
人乳头状瘤病毒感染与宫颈病变的相关性分析∗
The Investigation and Analysis of HPV Infection in Cervical Intraepithelial Neoplasia and Cervical Carcinoma
摘要
Abstract
Objective: To investigate 21 HPV genotypes infection in cervical cancer and cervical intraepithelial neoplasia ( CIN) , and the relationship between HPV infections and cervical cancer. Methods:Cases with chronic cervici-tis or abnormal cervical cells detected by liquid-based Thinprep cytology test ( TCT) had 21 HPV genotypes detected and accepted cervical biopsy during colposcopy. HPV infection status in 2 481 cases with cervical carcinoma or cervical intraep-ithelial neoplasia were analyzed. Results: Among 2 481 cases of CIN and cervical carcinoma, HPV-positive patients ac-counted for 85. 0%. There was statistically significant relevance between HPV infection and abnormal cervical histology (P<0. 001, Pearson correlation coefficient=0. 648). HPV16, HPV18 infection were most common in patients with CC and CINⅢ, CINⅡ, followed by HPV58, HPV 33, HPV31, HPV52, HPV45, HPV59, HPV68 subtype infections. In 304 pa-tients who got cervical infection with a subtype of HPV16, HPV18, HPV58, HPV52, HPV33, the incidence of high-grade squamous intraepithelial lesions (HSIL), atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) rose significant (P=0. 002, Pearson correlation coefficient=0. 322). Morover, CC, CIN III and CIN II had a high rate of HSIL, ASCUS. There were significant correlations between abnormal cervical cytology and histological results (P=0. 026, Pearson correla-tion coefficient=0. 172). Conclusion:Infection of high risk HPV types such as HPV16, HPV18, PHV58, HPV33, HPV52, HPV31, HPV45 is the main risk factor of cervical carcinoma ( CC) and precancerous lesion ( CIN) . With high-risk HPV infection, cervical cytologic diagnoses of HSIL, ASCUS and LSIL increase. The correlation between cytological and histological findings for CC and CIN promotes timely detection, prevention, intervention,and effective treatment.关键词
人乳头状瘤病毒/宫颈上皮内瘤变/宫颈癌/相关性Key words
Human Papilloma Virus/Cervical Intraepithelial Neoplasia/Cervical Carcinoma/Relevance分类
医药卫生引用本文复制引用
卢春冬,徐燕,任玉香,李玉艳,胡华,唐帅,包碧惠..人乳头状瘤病毒感染与宫颈病变的相关性分析∗[J].肿瘤预防与治疗,2014,(6):259-263,5.基金项目
国家自然科学基金编号81101994 （）
