肿瘤预防与治疗Issue(2)：71-76,6.DOI:10.3969/j.issn.1674-0904.2015.02.004
24例恶性间皮瘤临床分析
Report of 24 Patients with Malignant Mesothelioma
张芷旋 1张军 2陈晶 1周澄亚 1龙宇 1马洪丽 1蔡晓虹1
作者信息
- 1. 四川省肿瘤医院肿瘤内科，成都 610041
- 2. 四川省肿瘤医院肿瘤放疗科 成都 610041
- 折叠
摘要
Abstract
Objective:To investigate the clinicopathological characteristics of malignant mesothelioma (MM). Methods:Medical records of 24 malignant mesothelioma patients treated in our hospital from 1985 to 2014 were retrospec-tively reviewed.The clinical and pathological characteristics were analyzed.Results:Seventeen males and 7 females pa-tients were included in this study with a median age of 52 years.Eighteen patients were diagnosed as malignant pleural mesothelioma and 6 malignant peritoneal mesothelioma.Patients with malignant pleural mesothelioma presented most com-monly with chest pain (7 cases)and dyspnea after activities (6 cases),while abdominal distension (3 cases)occurred commonly in patients with malignant peritoneal mesothelioma.The most frequent radiological features were pleural effusion or peritoneal effusion (14cases).Seventeen cases were diagnosed via invasive procedures such as thoracoscopy,laparosco-py ,open pleural biopsy or open abdomen biopsy.Five cases were diagnosed via chest wall nodule or subcutaneous nodules excisional biopsy and 2 via pleural fluid immunocytochemistry.Pathological diagnoses included 20 cases of epithelioid sub-type ,2 biphasic sub-type and 2 non-specified sub-type.Seven cases (29.2%)were misdiagnosed at first visit and 4 pa-tients (16.7%)accepted anti-tuberculosis treatment before diagnosed.The median interval from start of complaints to diag-nosis was 3.3 months.Chemotherapy was administered to 21 patients,1 patient received radical surgery,8 patients re-ceived palliative surgery and palliative radiotherapy was given to 5 patients.The median survival from diagnosis to the end of follow up was 21 months.Conclusion:Malignant mesothelioma is an insidious tumor.A vast majority of MM patients are diagnosed in an advanced stage.The best treatment for the individual patient remains unknown.Multimodality treatment may alleviate symptoms and prolong the survival .关键词
恶性胸膜间皮瘤/恶性腹膜间皮瘤/临床特点Key words
Malignant Pleural Mesothelioma/Malignant Peritoneal Mesothelioma/Clinical Characteristics分类
医药卫生引用本文复制引用
张芷旋,张军,陈晶,周澄亚,龙宇,马洪丽,蔡晓虹..24例恶性间皮瘤临床分析[J].肿瘤预防与治疗,2015,(2):71-76,6.
