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聚(L-丙交酯-co-乙交酯)的制备及性能研究

侯昭升 孙斌 曲文强 董芳芳

生物医学工程研究Issue(1):29-31,43,4.
生物医学工程研究Issue(1):29-31,43,4.

聚(L-丙交酯-co-乙交酯)的制备及性能研究

Preparation and Properties of Poly(L-lactide-co-glycolide)

侯昭升 1孙斌 1曲文强 1董芳芳2

作者信息

  • 1. 山东师范大学化学化工与材料科学学院,山东 济南250014
  • 2. 山东赛克赛斯药业科技有限公司,山东 济南250100
  • 折叠

摘要

Abstract

The poly(L-lactide-co-glycolide)(PLGA),in which the mass fraction ratio of glycolide and L-lactide was 6∶4, were prepared by bulk ring-opening polymerization at high temperature and high vacuum using stannous octoate as catalyst and 1 ,4-butanediol as initiator.The chemical structure of the polymer was characterized by IR and 1 H NMR,and the properties were researched by DSC,TGA,XRD and rheometer.The results show that PLGA has high thermal stability and it is amorphous.The melt of PLGA is shear-thinning fluid,it has lower storage modulus and higher loss modulus.

关键词

乙交酯/L-丙交酯/聚(L-丙交酯-co-乙交酯)/开环聚合/性能

Key words

Glycolid/L-latide/Poly(L-lactide-co-glycolide)/Ring-opening polymerization/Properties

分类

医药卫生

引用本文复制引用

侯昭升,孙斌,曲文强,董芳芳..聚(L-丙交酯-co-乙交酯)的制备及性能研究[J].生物医学工程研究,2014,(1):29-31,43,4.

基金项目

山东省自然科学基金资助项目(ZR2013EMM004);国家级大学生创新计划资助项目(201101020236)。 ()

生物医学工程研究

OA北大核心CSTPCD

1672-6278

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