生物医学工程研究Issue(1)：11-14,22,5.
额叶肿瘤静息态功能磁共振比率低频振幅的研究
Study of Tumor with Frontal Lobe by the Fractional Amplitude of Low Frequency Fluctuation of Resting-state Functional Magnetic Resonance Imaging
摘要
Abstract
To investigate pathological mechanism of dysfunction of cognitive control in tumor in frontal lobe,using a resting-state functional magnetic resonance imaging (fMRI)index,fractional amplitude of low frequency fluctuation (fALFF).14 patients with tumor in frontal lobe and 14 gender,age and education-matched healthy controls were experienced resting-state fMRI scans.fALFF approach was used to analyze fMRI data in resting state.Compared with healthy control group,the group with frontal lobe tumor showed the increased value of fALFF in the right orbitofrontal,right temporal lobe,right supplementary motor area,left parahippocampal gyrus, left posterior cingulate gyrus,the left medial cingulate and paracentral lobule,in the bilateral dorsolateral frontal gyrus,bilateral medial frontal gyrus and Cerebelum.The results show the decreased functional activity in the frontal area of the resting state in the patient′s tumor in frontal lobe ,which is part of the frontal lobe tissue of the inactivation of tumor,whereas the rest of the default mode network re-gions and the enhancements of supplementary motor area may be related to cognitive dysfunction and compensatory effect.关键词
静息态/功能磁共振/比率低频振幅/额叶肿瘤/默认网络Key words
Resting-state/Functional magnetic resonance imaging (fMRI)/Fractional amplitude of low frequency fluctuation (fALFF)/Frontal tumor/Default mode network (DMN)分类
医药卫生引用本文复制引用
赵翠花,陶玲,俞宙,武江芬,孙金洋,周晖..额叶肿瘤静息态功能磁共振比率低频振幅的研究[J].生物医学工程研究,2015,(1):11-14,22,5.基金项目
国家自然科学基金资助项目（61075107）。 （）
