生物医学工程研究Issue(2)：110-114,5.
一种原位凝胶化温度敏感型液体栓塞材料--（Ⅰ）制备及性能研究
Synthesis and Characterization of a New Thermosensitive Polymer in Situ Gelation as Medical Liquid Embolic Material
朱肖杰 1朱小敏 2孟建文 3罗西友 4李红梅 3张素文 4王传栋 3冯圣玉4
作者信息
- 1. 山东大学化学与化工学院，济南 250100
- 2. 山东省药学科学院，济南 250101
- 3. 山东省医用高分子材料重点实验室，济南 250101
- 4. 山东省药学科学院，济南 250101
- 折叠
摘要
Abstract
Thermosensitive copolymers poly(NIP -co -BMA)of N -isopropylacrylamide (NIP)with Butyl Methacrylate (BMA) in situ gelation were synthesized by free radical copolymerization.FTIR results confirmed the structure of the monomer NIP and copoly-mer poly(NIP -co -BMA).The intrinsic viscosity and the lower critical solution temperature (LCST)of copolymer was investigated. The results indicated that the LCST was decreased with the higher concentration of BMA.The phase transition of the copolymers solu-tion occurred at body temperature and the copolymers changed the soft solids.The copolymers has a promise application in medical liq-uid embolic materials for arterial aneurysm.关键词
原位凝胶化/温度敏感型聚合物/非粘附性液体栓塞材料/N-异丙基丙烯酰胺/甲基丙烯酸丁酯Key words
In situ gelation/Thermosensitive copolymer/Nonadhesive liquid embolic materials/N -isopropylacrylamide/Butyl Methacrylate分类
医药卫生引用本文复制引用
朱肖杰,朱小敏,孟建文,罗西友,李红梅,张素文,王传栋,冯圣玉..一种原位凝胶化温度敏感型液体栓塞材料--（Ⅰ）制备及性能研究[J].生物医学工程研究,2015,(2):110-114,5.
