药学研究Issue(6)：341-344,4.
基于壳聚寡糖的黄芩苷固体分散体的研究
Studies on chitooligosaccharide applicatied in solid dispersion of baicalin
翟文婷 1史红军1
作者信息
- 1. 南京市高淳人民医院，江苏 南京211300
- 折叠
摘要
Abstract
Objective To prepare the solid dispersion of baicalin,using chitooligosaccharide with the intention of im-proving drug dissolution. Methods Baicalin solid dispersion was prepared by spray drying method with chitooligosaccharide as carriers. The physical characteristics and in vitro dissolution of baicalin solid dispersion were further evaluated. Results Dissolution percentages of solid dispersion prepared in the drug-carrier ratio of 1:6 was 94. 25% at 30 min. The differential scanning calorimetry( DSC)and scanning electron microscopy( SEM),X-ray powder diffraction( XRD)demonstrated that baicalin existed in amorphous state. Fourier transform infrared spectroscopy( IR)results indicated presence of interactions between chitooligosaccharide and baicalin. Conclusion The results indicated that solid dispersion prepared with chitooligo-saccharide as carrier can significantly increase dissolution of baicalin. As a new type carrier of solid dispersion,chitooligo-saccharide had its practical value.关键词
黄芩苷/壳聚寡糖/固体分散体/物相表征/溶出度Key words
Baicalin/Chitooligosaccharide/Solid dispersion/Physical characterization/Dissolution分类
医药卫生引用本文复制引用
翟文婷,史红军..基于壳聚寡糖的黄芩苷固体分散体的研究[J].药学研究,2014,(6):341-344,4.
