药学研究Issue(7)：391-394,4.
不同促透剂对人参皂苷 Rg1体外透皮吸收的影响
Effects of different penetration enhancers on transdermal absorption of ginsenoside Rg1 in vitro
摘要
Abstract
Objective To investigate the effects of different penetration enhancers on transdermal absorption of ginsen-oside rg1 in vitro through skin - penetrating experiments in mice,and determine the best penetration enhancer for laying the foundation for researching new transdermal absorption preparations. Methods Using the modified Franz diffusion pool method,with mice skin as transdermal barrier,physiological saline as accept medium,adding different penetration enhancers to make samples,with ginsenoside rg1 as quantitative indexes for transdermal absorption in vitro tests,measured by high performance liquid chromatography( HPLC) method,inspects the accumulation of ginsenoside rg1 through the vol-ume. Results Without penetration enhancers,ginsenoside rg1 had no accumulation;In single penetration enhancers,7%propylene glycol had the best effect,7% azone came second,borneol in aqueous solution had more lower effect;In compound penetration enhancers,the accumulation of azone ﹢ propylene glycol groups was closing at any concentrations;Effect of azone﹢ borneol group was better when both concentrations were at 2. 5% . Conclusion Common penetration enhancers as azone,propylene glycol and borneol can increase the accumulation of ginsenoside rg1 ,among them,7% propylene glycol was the best.关键词
人参皂苷 rg1/体外透皮吸收/促透剂Key words
Ginsenoside rg1/Transdermal absorption in vitro/Penetration enhancer分类
医药卫生引用本文复制引用
韩莉,王平,刘善新,苏酩,孙虎..不同促透剂对人参皂苷 Rg1体外透皮吸收的影响[J].药学研究,2014,(7):391-394,4.基金项目
山东省中医药科技发展计划项目（No.2011-154，2009-128）；山东省科技发展计划项目（No.2010GSF10278）；济南市青年科技明星计划［济科合字（2011）第01-0117号］ （）
