药学研究Issue(12)：739-741,3.
芬戈莫德的合成
Synthesis of fingolimod
刘剑峰 1苏鹏 1韩建奎 1侯桂华 2徐文方 3李月凯1
作者信息
- 1. 山东大学齐鲁医院，山东 济南250012
- 2. 山东大学医学院，山东 济南250012
- 3. 山东大学药学院，山东 济南250012
- 折叠
摘要
Abstract
Objective To synthesize fingolimod. Methods Fingolimod was synthesized with 2-phenethyl alcohol and sodium bromide as starting material,and through a series of reactions,such as substitution,acylation,condensation etc. Results The struture of target compound was confirmed by 1 H-NMR and MS. The overall yield of the process was 26. 9 % . Compared with the reported method,the overall yield was 6. 4% higher. Conclusion This synthetic process was convenient,and had high yield,low cost,and mild reaction condition. It was suitable for industrial production by its opera-tion,low cost and.关键词
2-苯乙醇/溴化钠/芬戈莫德/免疫抑制剂Key words
2-phenethyl alcohol/Sodium bromide/Fingolimod/Immunosuppressant分类
化学化工引用本文复制引用
刘剑峰,苏鹏,韩建奎,侯桂华,徐文方,李月凯..芬戈莫德的合成[J].药学研究,2014,(12):739-741,3.
