药学研究Issue(1)：4-6,3.
解郁方对抑郁模型小鼠脑内单胺类神经递质及单胺氧化酶含量的影响
The effects of Jieyufang on the content of monoamine neurotransmitter and monoamine oxidase in the brain of dePressive modeI mouse
摘要
Abstract
Pbjective To study the mechanism of antidepressant effect of Jieyufang. Methods To study the possible mechanism,the following methods had been carried out:the content of monoamine neurotransmitter was determined by enzyme—linked immunosorbent assay( ELISA);The content of monoamine oxidase in the mouse brain was determined by spectropho-tometry. ResuIts In the Jieyufang groupⅠ,Ⅱthe content of 5—HT,DA and NE in the brain increased significantly(p<0. 01, p<0. 05);The content of MAO in the brain decreased significantly(p<0. 01,p<0. 05). ConcIusion The mechanism of antidepressant may be associated with decrease the activity of MAO,increase the concentration of 5 —HT,NE,DA in the brain.关键词
抑郁症/解郁方/利血平模型/单胺类神经递质/单胺氧化酶/作用机理Key words
Depression/Jieyufang/Reserpine model mouse/Monoamine neurotransmitter/Monoamine oxidase/Mecha-nism of action分类
医药卫生引用本文复制引用
韩珍,贺弋..解郁方对抑郁模型小鼠脑内单胺类神经递质及单胺氧化酶含量的影响[J].药学研究,2015,(1):4-6,3.基金项目
宁夏自然科学基金项目 （）
