药学研究Issue(4)：225-228,4.
去势抵抗性前列腺癌分子信号通路的研究进展
Research progress on the molecular signaling pathway of castration-resistant prostate cancer
摘要
Abstract
In United States,prostate cancer is the most commonly diagnosed non-cutaneous cancer in males and the second leading cause of cancer-related death for men. Androgen and the androgen receptor( AR)are critical effectors of prostate cancer. Consequently,androgen deprivation therapy( ADT)is typically employed as a first-line treatment for pros-tate cancer patients. While initial responses are generally positive,prostate tumors frequently recur and progress to a lethal form known as castration-resistant prostate cancer( CRPC). To study the relationship between androgen receptor and the initiation and development of CRPC,along with the possible molecular mechanisms,helps to diagnosis and treatment of cas-tration-resistant prostate cancer( CRPC),and provide the basis for further research.关键词
去势抵抗性前列腺癌/雄激素受体/信号转导/分子机制Key words
Castration-resistant prostate cancer/Androgen receptor/Signal transduction/Molecular mechanism分类
医药卫生引用本文复制引用
张秀娜,赵伟,高晓芳,杨勇,季晖..去势抵抗性前列腺癌分子信号通路的研究进展[J].药学研究,2015,(4):225-228,4.基金项目
国家自然科学基金 （）
