药学研究Issue(6)：341-343,3.
均匀设计优化复方黄芩苷滴鼻凝胶基质处方
OPtimization of matrix formulation for ComPound Baicalin Gel Nasal DroPs By uniform design
孙迎东 1胡丽敏 1刘明华 1王玉 1汪风芹1
作者信息
- 1. 滨州医学院附属医院药学部，山东 滨州256603
- 折叠
摘要
Abstract
OBjective TooptimizethematrixformulationofDompoundBaicalinGelNasalDropsbyuniformde-sign.Methods Thematrixformulationwasoptimizedbyathreefactorandtenleveluniformdesign,withrheologicalpa-rameterssuchaspHvalue,viscosity,fluidity,appearanceandparticlesize.Results Theoptimummatrixformulationwas established as follows:0. 5 g carbomer-940,0. 75 g borax,10 mL phosphate buffer( pH 6. 0)in 100 g Dompound Baicalin Gel Nasal Drops. The Dompound Baicalin Gel Nasal Drops was pale yellow,transparent and colloidal liquid. The pH value was6.0.Theviscositywas2500~2800mPa·s.Conclusion TheDompoundBaicalinGelNasalDropspreparedbythe method had characteristics such as good drug stability and good applicability.关键词
黄芩苷/盐酸麻黄碱/均匀设计/基质Key words
Baicalin/Ephedrine hydrochloride/Uniform Design/Matrix分类
医药卫生引用本文复制引用
孙迎东,胡丽敏,刘明华,王玉,汪风芹..均匀设计优化复方黄芩苷滴鼻凝胶基质处方[J].药学研究,2015,(6):341-343,3.
