药学研究Issue(6)：365-367,3.
依普利酮的合成
Synthesis of ePlerenone
商艳梅 1郑忠辉 1赵淑娟1
作者信息
- 1. 山东新华制药股份有限公司，山东 淄博255086
- 折叠
摘要
Abstract
With Δ9(11)-canrenone as raw material,eplerenone was obtained after a series of reaction process,inclu-ding sodium cyanide addition to give enamine( compound 4),hydrolysis to diketone( compound 3). After ring opening and eliminating in presence of sodium methoxide,diketone(compound 3)was converted to methyl ester(compound 2). Finally, epoxidation of compound 2 was performed by reaction with H2 O2 in the presence of trichloroacetamide or trichloroacetonitrile and K2 HPO4 ,giving eplerenone.关键词
Δ9(11)坎利酮/依普利酮/合成Key words
Δ9(11)-canrenone/Eplerenone/Synthesis分类
化学化工引用本文复制引用
商艳梅,郑忠辉,赵淑娟..依普利酮的合成[J].药学研究,2015,(6):365-367,3.
