药学研究Issue(7)：373-375,386,4.
半边旗提取物5F联合5-Fu对A/J小鼠诱发性肺癌的影响
Protective effect of 5F,an extract from Pteris semipinnata L,in combine with 5 - Fu,on development of lung cancer in A/J mice
摘要
Abstract
Objective To investigate the effect of 5F,an extract from Pteris semipinnata L,in combine with 5 - Fu,on the model of induced A/ J mice lung cancer. Methods Intragastric administration was conducted on all mice using mixed re-vulsant of B[a]P and NNK. The aforementioned operation was performed once per week and continued for 8 weeks. 5F and 5- Fu,alone or in combination,were injected into mice from the ninth week and continued for 14 weeks. Count the number of lung cancer and calculate the tumor inhibition rate. Weight the liver and kidney,and calculate the organ index. The levels of ALT,AST,BUN,Scr,SOD and MDA were also detected. Results The combined application of 5F and 5 - Fu significantly suppressed the development of B[a]P and NNK - induced lung cancer in vivo with minimal side effects,and increase the level of serum SOD. Conclusion 5F combined with 5 - Fu had a synergistic effect on the induced lung cancer in A/ J mice.关键词
5F/半边旗/肺癌/甲基亚硝胺吡啶基丁酮/苯并a芘Key words
5F/Pteris semipinnata L/Lung cancer/NNK/B[a]P分类
医药卫生引用本文复制引用
叶华,刘义,吴科锋,李立,郑学宝..半边旗提取物5F联合5-Fu对A/J小鼠诱发性肺癌的影响[J].药学研究,2015,(7):373-375,386,4.基金项目
国家自然科学基金（No.30772701）；广东省科技计划项目（No.2009C3104003）；广东医学院重点项目（No. Z2013001）和博士启动项目 （）
