山东中医药大学学报Issue(5)：415-419,5.
人类抗病毒感染的“RNAi自限假说”及其初步论证
Preliminary Demonstration of “RNAi Self-limiting Hypothesis” for Human Anti-virus Infection Based on Balance Theory of Traditional Chinese Medicine
摘要
Abstract
A new hypothesis for human anti-virus infection,named RNAi self-limiting hypothesis,is proposed in the paper. In the endogenous reverse transcriptase and integrase mediated ,viral mRNAs are randomly re-verse transcribed into cDNAs in host cell,some of which are integrated into human genome,and further transcribed into an immunospecific RNA(imRNA) with the function of inhibiting of the same viral multipli-cation in infected cells by the RNA interference mechanism. imRNA activates host small RNA-dependent defense mechanisms to suppress the viral multiplication,and establish a latent infection state between virus and host,which host remains persistently viral infection at low level without obvious signs of disease. This hypothesis is initially tested from three aspects of the existence of the reverse transcriptase-like and inte-grase-like genes in human genome,the existence of viral homologous sequences in human genome,and virus-infected animal model. Furthermore,implication of hypothesis in forecasting viral disease epidemic trend is briefly discussed in the paper. The hypothesis was spiritual communion with the traditional Chinese medicine theory “balance”. Establishing a harmonious coexistence of latent infection between virus and host by intervening their interaction program with Chinese medicinal,rather than killing virus directly,should be a new idea on research and development of antiviral medicine.关键词
中药/病毒/免疫RNA/RNA干扰/潜伏感染Key words
Chinese medicinal/virus/immunospecific RNA/RNA interference/latent infection分类
医药卫生引用本文复制引用
王厚伟,田景振,杨振宁,张成博..人类抗病毒感染的“RNAi自限假说”及其初步论证[J].山东中医药大学学报,2014,(5):415-419,5.基金项目
山东省自然科学基金（编号ZR2013HM035）；国家科技部重大新药创制专项 （）
