山东中医杂志Issue(11)：914-916,3.
白花蛇舌草抑制肝癌H22小鼠淋巴管转移的实验研究
Experimental Study on Inhibitory Effect of Hedyotis Diffusa Willd on Lymphatic Metastasis of Mice with Hepatocarcinoma H22
摘要
Abstract
Objective:To observe effects of Hedyotis diffusa Willd in treating hepatocarcinoma lymphatic metastasis of mice. Methods:The H22 lymphatic metastasis models were established by subcutaneous injecting H22 cell line into the palmula of right lower limb. The model mice were randomly divided into 5 groups. The blank group was given normal saline daily,and large,medium,small-dose group were given Hedyotis diffusa Willd,and the control group were received cyclophosphamide by intraperitoneal injection daily. The changes of mouse’s body weight,the weight of immune organ,lung metastasis,paw pads transplantation tumor and lymph node metastasis were observed. Results:In Hedyotis diffusa Willd group,body weight and the weight of immune organs increased,lung nodules and lung metastasis tumor growth index were decreased,and the number of lymph node metastases was reduced. Conclusion:Hedyotis diffusa Willd has an inhibitory ef-fect on the metastasis of hepatocarcinoma lymphatic.关键词
白花蛇舌草/肝癌H22/抗肿瘤/淋巴管转移/小鼠Key words
Hedyotis diffusa Willd/hepatocarcinoma H22/anti-tumor/lymphatic metastasis/mice分类
医药卫生引用本文复制引用
李洁,李怀芝,韩冰冰..白花蛇舌草抑制肝癌H22小鼠淋巴管转移的实验研究[J].山东中医杂志,2014,(11):914-916,3.基金项目
山东省自然科学基金课题 （）
