山东中医杂志Issue(6)：454-456,3.
小半夏汤对化疗性异食癖模型大鼠血清胃肠激素的影响
Effect of Xiaobanxia Decoction on Gastrointestinal Hormone in Chemotherapy-induced Pica in Model Rats
摘要
Abstract
Objective:In order to explore the anti-emetic mechanism of Xiaobanxia decoction (XBXT),its ef-fect on gastrointestinal hormone level was observed in chemotherapy-induced pica rats. Methods:Sixty male Wistar rats were randomly divided into normal control,XBXT control,cisplatin model,ondansetron,XBXT high dose and low dose groups. Pica model was induced by cisplatin 6 mg/kg i.p.. One hour before and 11 hour after cisplatin injection,each group was gavaged with distilled water,XBXT 0.8 g/kg,ondansetron 1.3 mg/kg, distilled water,XBXT 1.6 g/kg and 0.8 g/kg respectively. After 24 h of cisplatin injection,gastrointestinal hor-mones in serum were measured using ELISA method. Results:Both dosages of XBXT could significantly in-hibit rat pica (P<0.01),and reverse the abnormal increase of somatostatin and VIP (P<0.05) and abnormal decrease of gastrin and motilin(P<0.05). Conclusion:The mechanism of XBXT on the treatment of chemother-apy-induced nausea and vomiting was related to ameliorate the disorders of gastrointestinal hormone.关键词
小半夏汤/化疗性恶心呕吐/胃肠激素/大鼠Key words
Xiaobanxia decoction/chemotherapy-induced nausea and vomiting/gastrointestinal hormone/rat分类
医药卫生引用本文复制引用
张勇,于功昌,聂克..小半夏汤对化疗性异食癖模型大鼠血清胃肠激素的影响[J].山东中医杂志,2015,(6):454-456,3.基金项目
国家自然科学基金面上项目（编号81373828）；山东省自然科学基金项目（编号ZR2012HM058）；高等学校博士学科点专项科研基金联合资助课题（编号20123731110004）。 （）
