山东农业科学Issue(6)：123-125,3.
重组禽流感病毒 H5亚型二价灭活疫苗免疫 SPF 鸡、SPF 鸭后抗体消长规律分析
Antibody Response Dynamics in SPF Chicks and Ducks Immuned with Inactivated Avian Influenza Vaccines
摘要
Abstract
This experiment was carried out to know about the immune effect of bivalent inactivated vac-cines, recombinant H5N1 subtype avian influenza virus (H5N1, Re-6 strain +Re-4 strain), and provide clinical basis for formulating the avian influenza vaccine immune program .Twelve batches of vaccine from three companies were used for the immune of SPF chicks and ducks .Each chick or duck serum was separately collected every three weeks after immunization up to twenty -four weeks .The serum antibody titer of Re -6 and Re-4 were detected .It was showed that the HI titer of the immunized SPF chicks and ducks reached the peak after 6 and 3 weeks of the first immunization , respectively;over time , the antibody titer decreased gradu-ally;the antibody peak of SPF chicks was higher than that of SPF ducks; the duration of high antibody titer maintained longer in SPF chicks .It was proved that all the vaccines induced good immune responses in chicks and ducks .关键词
禽流感灭活疫苗(H5N1,Re-6株+Re-4株)/SPF鸡/SPF鸭/抗体消长规律Key words
Avian influenza inactivated vaccines ( H5N1, Re -6 strain +Re -4 strain )/SPF chicks/SPF ducks/Antibody response dynamics分类
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董以雷,徐怀英,刘涛,王春玲,王友令,王莉莉,亓丽红,艾武..重组禽流感病毒 H5亚型二价灭活疫苗免疫 SPF 鸡、SPF 鸭后抗体消长规律分析[J].山东农业科学,2014,(6):123-125,3.基金项目
山东省中标禽流感疫苗质量监测项目 （）
