山东医药Issue(14)：1-4,4.DOI:10.3969/j.issn.1002-266X.2014.14.001
地塞米松早期干预对犬胸部开放伤海水浸泡所致急性肺损伤的治疗作用及机制探讨
Effect of early intervention of dexamethasone for acute lung injury following open chest trauma and sea water immersion in dogs and the mechanism
摘要
Abstract
Objective To investigate the effect of dexamethasone for acute lung injury ( ALI ) following open chest trauma and sea water immersion in dogs and its mechanism .Methods Sixteen healthy adult dogs were used to make the ALI models by seawater immersed thoracic cavity after open chest trauma .Then the ALI models were randomly assigned in-to the control group ( CG) and the dexamethasone treatment group ( DG) , 8 in each group .Dogs in the DG group were in-travenously injected with 1 mg/kg dexamethasone ( DG) 30 min after open chest trauma and sea water immersion , and dogs in the CG group were treated with equal normal saline .Arterial blood gas indexes (PaO2 and PaO2/FiO2) and expression changes of alveolar surfactant protein-A ( SP-A) and alveolar surfactant protein-B ( SP-B) in the lung bronchoalveolar lav-age fluid ( BALF) and serum as well as the EVL-WI and ELI were observed .Results At 4 h after treatment , the PaO2 and PaO2/FiO2 in the DG group was significantly higher than that of the control group (P<0.05), the EVL-WI and ELI in the DG group was lower than that of the control group (P<0.05), and the SP-A and SP-B in the DG group in the BALF was higher than that of the CG group but lower than in the blood serum .Conclusion Dexamethasone can relieve hypoxia and pulmonary edema after open chest trauma and sea water immersion in dogs and its mechanism may be associated with the increase of the SP-A and SP-B contents in lungs .关键词
急性肺损伤/海水浸泡/肺泡表面活性蛋白A/肺泡表面活性蛋白B/地塞米松Key words
acute lung injury/seawater immersion/alveolar surfactant protein-A/alveolar surfactant protein-B/dex-amethasone分类
医药卫生引用本文复制引用
李毅,段蕴铀,韩志海,刘于红..地塞米松早期干预对犬胸部开放伤海水浸泡所致急性肺损伤的治疗作用及机制探讨[J].山东医药,2014,(14):1-4,4.基金项目
中国人民解放军“十一五”全军后勤科研计划课题（2006-3304）。 （）
