山东医药Issue(14)：18-21,4.DOI:10.3969/j.issn.1002-266X.2014.14.007
右心房组织中 M3受体及缝隙连接蛋白43与心房颤动的相关性研究
Roles of M3 receptor and Cx43 in human atrial fibrillation
摘要
Abstract
Objective To investigate the potential roles of M 3 receptor and connexin 43 ( Cx43 ) in the occurrence and maintenance of human atrial fibrillation ( AF) and the relationship between them .Methods The right atrial tissues were obtained from 94 patients with rheumatic heart disease undergoing cardiac surgery , and then were divided into group AF (n=49), and sinus rhythm group (group SR, n=45).The co-localization of M3 receptor and Cx43 was detected by immunofluorescence and confocal microscopy .The expression levels of M3 receptor and Cx43 protein were measured by Western blotting.Results Compared with group SR, the expression levels of M3 receptor and Cx43 protein were signifi-cantly down-regulated (P<0.05), while the co-localization of M3 receptor and Cx43 were enhanced in the group AF (P<0.05).Conclusions The down-regulation of Cx43 in the right atrial tissues of AF patients may be one of the mechanisms of occurrence and maintenance of AF , and the decrease of M3's expression and increase of co-localization of M3 receptor and Cx43 may be the protective mechanisms of preventing atrial electrical remodeling produced by cardiomyocytes .关键词
心房颤动/M3受体/缝隙连接蛋白43Key words
atrial fibrillation/M3 receptor/connexin 43分类
医药卫生引用本文复制引用
李烁,钟国强,何艳,肖飞,蒋智渊,蒙滋滋..右心房组织中 M3受体及缝隙连接蛋白43与心房颤动的相关性研究[J].山东医药,2014,(14):18-21,4.基金项目
广西自然科学基金资助项目（2013GXNSFAA019167）。 （）
