山东医药Issue(16)：1-3,3.DOI:10.3969/j.issn.1002-266X.2014.16.001
miR-146a基因多态性与腔隙性脑梗死的关系
Association between miR-146 a gene polymorphism and lacunar infarction
摘要
Abstract
Objective To investigate the association between miR-146a gene polymorphism and lacunar infarction ( LI) .Methods The present study recruited 173 patients with LI ( observation group ) and 298 age-and sex-matched out-patient controls without cardiovascular and cerebrovascular diseases ( control group ) .Multiplex SNaPshot was employed to determine the genotype and allele frequencies of rs 2910164 and rs57095329 polymorphisms of the miR-146a gene.B-color Doppler ultrasonography was used to determine the carotid artery intima-media thickness ( CIMT) .Results The frequen-cies of the GG genotype , CC+CG genotype and G allele in the observation group were 8.67%, 91.33%and 33.24%, re-spectively;While the frequencies in the control group were 17.11%, 82.89%and 39.93%, respectively (all P<0.05). The genotype and allele frequencies of rs57095329 were not statistically associated with LI (all P>0.05).The frequency in patients below 70 years old of the observation group carrying the G allele of miR-146a rs2910164 polymorphism was 28.57%, and the frequency in the control group was 39.12% (P<0.05).The CIMT of common genotype and mutant genotype between rs2910164 and rs57095329 polymorphisms of miR-146a in the observation group was not significantly dif-ferent (all P>0.05).Conclusion The present study suggests that the frequency of the G allele of miR-146a rs2910164 is lower in LI patients and the rs 2910164 G allele is likely to play a protective role in the etiology of lacunar infarction .关键词
脑小血管病/腔隙性脑梗死/微小RNA-146a/基因多态性Key words
cerebral small vessel diseases/lacunar infarction/microRNA-146a/gene polymorphism分类
医药卫生引用本文复制引用
李友,朱菁,马国达,李克深,崔理立..miR-146a基因多态性与腔隙性脑梗死的关系[J].山东医药,2014,(16):1-3,3.基金项目
国家自然科学基金资助项目（81300929）。 （）
