摘要
Abstract
Objective To evaluate the efficacy of atorvastatin combined with gemfibrozil in treatment of combined hy -perlipidemia in rats.Methods Forty-eight Wistar rats were randomized into group N , group C, group A and group AJ, 12 rats in each group.The experimental process took 8 weeks, 4 weeks of modeling and 4 weeks of medication.The rats in each group were fed with high fatty food , except group N .Groups N and C were not given the drug intervention , but group A was administered with atorvastatin 1.8 mg/kg/d in the evening and group AJ was treated with atorvastatin 0.9 mg/kg/d +gemfi-brozil 54 mg/kg/d, respectively in the morning and in the evening .The plasma lipid were measured at week 4 and 8, moreo-ver, the hepatic pathological slices were observed at week 8.Results At week 4, the levels of TC, LDL-C, TG, Lp(a) in the groups C, A and AJ were higher than that of group N (all P<0.01);at week 8, the levels of TC, LDL-C, TG and Lp (a) of groups A and AJ were lower than that of group C (all P<0.01), the level of HDL-C was higher, and TG level was lower in the group AJ as compared with that of group A (all P<0.01).Group N showed no liver fatty degeneration and nec-rosis, but in group C, the steatosis was almost 100%, the degree of fatty degeneration significantly reduced in group A , and the fatty degeneration in group AJ improved better than that of group A .Conclusions Combined therapy of atorvastatin plus gemfibrozil can strengthen the effects on adjusting lipids , controlling the inflammation and relieving the fat degeneration in liv-er tissues of rats .关键词
混合性高脂血症/阿托伐他汀/吉非罗齐/大鼠Key words
combined hyperlipidemia/atorvastatin/gemfibrozil/rat分类
医药卫生
