山东医药Issue(20)：1-4,8,5.DOI:10.3969/j.issn.1002-266X.2014.20.001
精神分裂症、神经症、抑郁症患者的脑电超慢涨落图分析
Analysis of related factors by encephaloflugram technology on patients with schizophrenia, neurosis, depression
摘要
Abstract
Objective To observe the differences of neurotransmitters , brain function and entropy values in 0-29 year-old outpatients with schizophrenia , neurosis, and depression by encephaloflugram technology (ETG).Methods The outpa-tients with schizophrenia , neurosis and depression were tested once by encephaloflugram technology , then the differences be-tween the neurotransmitters , brain function, and entropy values were analyzed .Results The Ach and INH were significantly higher in patients with schizophrenia than the normal (all P<0.05), but GABA and DA were significantly below the normal (all P<0.05).5-HT and Ach in patients with neurosis were significantly higher than normal (all P<0.05).Ach and INH in patients with depression were significantly higher than normal (all P<0.05), while GABA, NE and DA were significantly lower than the normal (all P<0.05).Comparison between different sexes with the same disease showed that the GABA of male patients with schizophrenia was significantly lower than that of females (P<0.05).Comparison between the same men suffering from different diseases showed that significant differences were found in GABA and age (all P<0.05).On brain function , the ratio in cerebral ischemia and hypoxia′s normal female patients with depression was the least as well as excitato-ry and inhibitory male patients with neurosis .Comparison between different diseases′entropy and the normal showed that schizophrenia, neurosis, depression′s brain entropy was in the normal range , patients with schizophrenia had maximum entro-py and worst orderly brain , and patients with neurosis had the minimum entropy and the best order .Three diseases′entropy analysis of variance found that there were significant differences in C 4, T4, T5, P4, T6, O1 and O2 leads (all P<0.05). Comparison between the different gender entropy values of the same disease found that there were significant difference in FP1 and F8 of patients with schizophrenia between men and women (all P<0.05).Significant difference was found in T6 between neurosis men′s entropy values and women′s (P<0.05).Comparison between different diseases′lead entropy of the same female patients showed that there were significant differences in F7, C3, C4, T4, T5, P4, T6, O1 and O2 (all P<0.05).Conclusion The decrease of the GABA function may be the main reason of neuropsychiatric diseases .Women with depression are accompa-nied by symptoms of ischemia and hypoxia, and the self-restraint of male neurotic patients is more evident.The differences of GABA levels, the brain order and temporal, occipital entropy may help in the differential diagnosis of the three diseases .关键词
精神分裂症/神经症性障碍/抑郁症/神经递质/脑电超慢涨落图/脑功能/熵Key words
schizophrenia/neurosis disorder/depression/neurotransmitters/encephaloflugram technology/brain function/entropy分类
医药卫生引用本文复制引用
蒋帅,吴银侠,王大刚,刘光雄,马文涛,杨来启..精神分裂症、神经症、抑郁症患者的脑电超慢涨落图分析[J].山东医药,2014,(20):1-4,8,5.基金项目
军队中医药科研专项课题（10ZYX108）；2012年军区医药卫生科研课题（CWS10JA03CLZ12JB23）。 （）
