山东医药Issue(20)：24-27,4.DOI:10.3969/j.issn.1002-266X.2014.20.007
乙醛对大鼠心肌细胞线粒体功能的影响
Effects of acetaldehyde on the myocardial mitochondrial function of rats
摘要
Abstract
Objective To investigate the effects of different dosages of acetaldehyde on the activity variation of myo -cardial mitochondrial succinate dehydrogenase ( SDH) of rats by intraperitoneal injection and observe the histomorphology of myocardial mitochondria by transmission electron microscope ( TEM) in order to further discover the possible mechanism of myocardium injury by ethanol .Methods Sixty-five Wistar rats were randomly divided into four groups:the control group (n=20, group C), low dose acetaldehyde group (n=15, group L), high dose acetaldehyde group (n=15, group H) and levocarnitine group (n=15).Acetaldehyde (110 mg/kg and 220 mg/kg) were injected into the rats′abdominal cavi-ties once a day for 4 weeks .TEM was applied to observe the mitochondrial histomorphology of all groups .SDH activity in the myocardium, superoxide dismutase ( SOD) and malondialdehyde ( MDA) in plasma were detected by biochemical methods .Results Compared with group C , under the TEM , we observed that the mitochondria swelled , and the ridge dis-appeared with incomplete or no capsule in group L , group H and levocarnitine group .The SDH activity of the levocarnitine group was significantly higher than of that of group H (P<0.05) as well as the content of SOD (P<0.05), but the con-tent of MDA was significantly lower than that of group H (P<0.05).Conclusions The intraperitoneal injection of acetal-dehyde could damage the myocardial cells of rats , especially resulting in the myocardial mitochondrial impairment .Oxida-tive stress may take part in the process of myocardial injuries , and levocarnitine may reduce the myocardial damage of acet-aldehyde .关键词
乙醛/酒精性心肌病/线粒体/琥珀酸脱氢酶/超氧化物歧化酶/丙二醛Key words
acetaldehyde/alcoholic cardiomyopathy/mitochondria/succinate dehydrogenase/superoxide dismutase/malondialdehyde分类
医药卫生引用本文复制引用
王国锋,林英子,段志英,柳兢,王琦,周东晖,金元哲..乙醛对大鼠心肌细胞线粒体功能的影响[J].山东医药,2014,(20):24-27,4.基金项目
国家自然科学基金资助项目（51272287）。 （）
