山东医药Issue(26)：39-41,3.DOI:10.3969/j.issn.1002-266X.2014.26.014
CA19-9与 K-ras 基因突变联合检测诊断胰腺癌的价值
Combined detections of CA19-9 and K-ras gene mutation for diagnosis of pancreatic cancer
摘要
Abstract
Objective To investigate the effects of combined detections of carbohydrate antigen 19-9 ( CA19-9 ) and K-ras gene mutation for diagnosis of pancreatic cancer .Methods Thirty-one patients with pancreatic cancer undergoing surgery ( the pancreatic cancer group ) and 22 cases with pancreatic benign lesions undergoing surgery ( the benign group ) were selected .The CA19-9 level in the peripheral blood was detected by electrochemiluminescence and the positive (>39 U/mL) rate of CA19-9 was calculated in the two groups; K-ras gene 12 codon mutations were detected by mutant allele-specific amplification ( PCR-MASA) and K-ras gene mutation rate was calculated .Results The CA19-9 positive rate and the K-ras gene mutation rate of pancreatic cancer group were significantly higher than those of the benign group ( all P<0.05).K-ras gene mutation rate was 80.6% (25/31).The sensitivity, specificity, positive predictive value , negative predictive value and accuracy of combined detections of CA 19-9 and K-ras gene in diagnosis of pancreatic cancer were all higher than those of the single detection of CA 19-9 and K-ras gene .Conclusion The combined detections of CAl 9-9 and K-ras gene are more helpful in the early diagnosis of pancreatic cancer than the single detection .关键词
胰腺肿瘤/K-ras基因/外周血糖链抗原19-9/联合检测Key words
pancreatic neoplasms/K-ras gene/carbohydrate antigen 19-9/tumor marker分类
医药卫生引用本文复制引用
刘香吉,刘福国,赵洁,刘世海,江月萍..CA19-9与 K-ras 基因突变联合检测诊断胰腺癌的价值[J].山东医药,2014,(26):39-41,3.基金项目
青岛市软科学研究计划项目［11-2-3-（12）-nsh］。 （）
