山东医药Issue(27)：14-17,4.DOI:10.3969/j.issn.1002-266X.2014.27.005
贲门腺癌组织中 RKIP、NF-κBp65的表达变化及意义
Expression changes and significance of Raf kinase inhibitor protein and nuclear factor-κBp65 in gastric cardia adenocarcinoma
摘要
Abstract
Objective To observe the expression changes of Raf kinase inhibitor protein ( RKIP) and nuclear factor-κBp65 (NF-κBp65) in gastric cardia adenocarcinoma (GCA) and to discuss the significance.Methods The expression of RKIP and NF-κBp65 in cancerous tissues ( carcinoma group ) and the paracancerous tissues ( adjacent group ) from 160 GCA patients were detected by immunohistochemistry assay .The relationships between the two indexes and with the clinical and pathological features of GCA were analyzed .Results The positive expression rates of RKIP in the cancerous tissues and paracancerous tissues were 38.75%and 52.5%, respectively;the difference was significant (P<0.01).The positive expression rates of NF-κBp65 in the two groups were 75 .625% and 20 .000%, and the difference was significant ( P<0.01).The positive expression rate of RKIP was associated with lymph node metastasis in GCA (P<0.05).The positive expression rate of NF-κBp65 was associated with clinical staging , differentiation of the cancer and lymph node metastasis (all P<0.05).Negative correlation was found between the expression of RKIP and NF-κBp65 in GCA (r=-0.431, P<0.01).Conclusions The expression of RKIP is down-regulated and NF-κBp65 is up-regulated in the GCA tissues .The invasion and metastasis of GCA are promoted by the up-regulation of NF-p65 expression and down-regulation RKIP expres-sion.关键词
贲门腺癌/Raf激酶抑制蛋白/核因子-κBp65Key words
gastric cardia adenocarcinoma/Raf kinase inhibitor protein/nuclear factor-κBp65分类
医药卫生引用本文复制引用
魏红,齐淑静,刘文利,徐亮,李丽东,李华,董稚明,张向阳..贲门腺癌组织中 RKIP、NF-κBp65的表达变化及意义[J].山东医药,2014,(27):14-17,4.基金项目
河北省科技公关计划项目（14277765D）。 （）
