山东医药Issue(29)：15-17,3.DOI:10.3969/j.issn.1002-266X.2014.29.006
噻托溴铵治疗稳定期中重度慢性阻塞性肺疾病的效果观察
Efficacy of tiotropium in treatment of moderate and severe stable chronic obstructive pulmonary disease
姬峰 1韩智国 1闫金波 2许韫 1袁圆1
作者信息
- 1. 武警山东总队医院，济南250014
- 2. 武警山东总队卫生处
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of inhaled tiotropium in treatment of patients with moderate to severe stable chronic obstructive pulmonary disease (COPD).Methods Fifty-six patients with moderate to severe COPD in stable phase were randomly divided into the observation group and control group , 28 in each group.Patients in the con-trol group were treated with symbicort turbuhaler , and patients in the observation group received tiotropium combined budesonide therapy.Both the courses of treatment were 48 weeks.The pulmonary function test, the number of acute epi-sodes, intervals between attacks , SGRQ and MMRC were observed after drug administration in the two groups .Results The first second forced expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC% and inspiratory capacity (IC) were significantly improved after being treated with tiotropium for 48 weeks (all P<0.05).Compared with the con-trol group, the values of FEV1, FVC, FEV1/FVC%and IC were significantly increased in the observation group (all P<0.05).The numbers of acute episodes was less , the intervals between attacks was longer and the life quality scores im-proved in both the two groups as compared with those before treatment (all P<0.05), and the observation group improved much better than the control group .Conclusion Tiotropium could improve pulmonary function , reduce the number of ex-acerbations and intervals , improve quality of life in patients with stable COPD with high safety , which is worthy of clinical promotion.关键词
肺疾病,慢性阻塞性/噻托溴铵/肺功能Key words
pulmonary disease , chronic obstructive/tiotropium/lung function分类
医药卫生引用本文复制引用
姬峰,韩智国,闫金波,许韫,袁圆..噻托溴铵治疗稳定期中重度慢性阻塞性肺疾病的效果观察[J].山东医药,2014,(29):15-17,3.
