山东医药Issue(30)：4-6,3.DOI:10.3969/j.issn.1002-266X.2014.30.002
子宫内膜异位症患者血清及腹腔液sflt-1表达变化及意义
Expression of vascular endothelial growth factor soluble receptor in the serum and peritoneal fluid of EMs patients
摘要
Abstract
Objective To detect the expression of vascular endothelial growth factor soluble receptor ( sflt-1 ) in the serum and peritoneal fluid of the EMs patients and explore it's clinical siginificance .Methods A total of 48 EMs patients including 15 ⅠtoⅡstage patients and 33ⅢtoⅣstage patients .Thirty patients cured by the laparoscopic surgery with-out EMS were involved as control group .The expressions of VEGF and sflt-1 in the serum and peritoneal fluid of the two group patients were detected by using ELISA .VEGF activity index was calculated .Results The serum and peritoneal flu-id level of VEGF and sflt-1 as well as VEGF activity index in EMs group were both higher than those of control group ( all P<0.05).The serum and peritoneal fluid level of VEGF and sflt-1 as well as VEGF activity index in stage ⅢtoⅣpatients were both higher than those of stage ⅠtoⅡpatients(all P<0.05).Conclusions Anti-angiogenic factor expression ab-normalities may be related to the pathogenesis of endometriosis .The sFlt-1 may be a new treatment targets .关键词
子宫内膜异位症/血管内皮生长因子/血管内皮生长因子可溶性受体Key words
endometriosis/vascular endothelial growth factor/vascular endothelial growth factor soluble receptor分类
医药卫生引用本文复制引用
李艳芳,史淑红,李腾华,李荣霞..子宫内膜异位症患者血清及腹腔液sflt-1表达变化及意义[J].山东医药,2014,(30):4-6,3.基金项目
河北省科技计划项目（12277740）。 （）
