山东医药Issue(31)：18-20,3.DOI:10.3969/j.issn.1002-266X.2014.31.006
甲基强的松龙鞘内注射治疗急性期多发性硬化的临床疗效及其对患者T淋巴细胞亚群的影响
Efficacy of intrathecal injection of methylprednisolone in treatment of multiple sclerosis and its effect on T-lymphocyte subsets
摘要
Abstract
Objective To observe the efficacy of intrathecal injection of methylprednisolone ( MPS) in treatment of multiple sclerosis ( MS) and its effect on T-lymphocyte subsets .Methods Eighty patients with acute MS were divided into the MPS intrathecal injection group (35 cases) and MPS impact group (45 cases).The two groups were treated with con-ventional neurotrophic drugs , and then were treated with intrathecal injection of MPS and conventional intravenous impact therapy .Flow cytometry was used to evaluate the levels of T-lymphocyte subsets and peripheral blood of the two groups be-fore and after treatment for 2 weeks.Then we evaluated the neurological scores by using Kurtzke expanded disability status scale (EDSS).Results After treatment for 5 days, the ΔEDSS in the MPS intrathecal injection group was higher than that in the MPS impact group (t=17.516, P<0.05), but no difference was found between the two groups after treatment for 10 and 15 days (all P>0.05).The CD4+decreased and CD8+increased in cerebrospinal fluid (CSF), and the CD4+increased and the CD 4+/CD8+decreased in the peripheral blood of the two groups after treatment as compared with those be -fore treatment.The difference in the indexes of T-lymphocyte subsets was not statistical significant between the two groups after treatment (all P>0.05).Conclusions Intrathecal injection of MPS in treatment of MS works faster and the neuro-logical function improves better as compared with the MPS impact therapy .With the remission of the disease , there are dif-ferent degrees of improvement in the T-lymphocyte subsets .关键词
多发性硬化/甲基强的松龙/鞘内注射/T淋巴细胞Key words
multiple sclerosis/methylprednisolone/intrathecal injection/T-lymphocyte subsets分类
医药卫生引用本文复制引用
董艳玲,李吕力,李瑶宣,梁浩,滕晓茗..甲基强的松龙鞘内注射治疗急性期多发性硬化的临床疗效及其对患者T淋巴细胞亚群的影响[J].山东医药,2014,(31):18-20,3.基金项目
广西科学研究与技术开发计划课题（桂科攻0898010）；广西壮族自治区卫生厅科研课题（Z2008085）。 （）
