山东医药Issue(35)：19-22,4.DOI:10.3969/j.issn.1002-266X.2014.35.006
尿毒症继发难治性甲状旁腺功能亢进症患者心脏瓣膜钙化情况及影响因素
Analysis of relative factors of heart valve calcification in patients with refractory secondary hyperparathyroidism
摘要
Abstract
Objective To analyze the incidence of heart valve calcification(VC) and the possible factors of heart valve calcification among patients with refractory secondary hyperparathyroidism.Methods A total of 83 cases with refrac-tory SHPT treated with parathyroidectomy (PTX) were retrospectively studied.The levels of hemoglobin(Hb), albumin ( Alb) , calcium( Ca2+) , phosphorus( P) , alkaline phosphatase( ALP) , CRP and intact parathyroid hormone( iPTH) were detected before hemodialysis.Heart valve calcification and parameters relating to cardiac structure and function were as-sayed, the patients were then assigned into the VC group and the no VC group.Laboratory and clinical data were compared between the two groups, then analyzed the possible factors contribute to VC.Results The incidence of VC were 47%(39/83)in SHPT patients.Mitral valve calcification were found in 18 patients(46.15%), mitral and aortic valve calcifi-cation in 17 patients(43.59%), aortic valve calcification in 4 patients (10.26%), 43.37% (36/83) of patients had a heart valve regurgitation( mitral valve and aortic valve) .The level of SBP, DBP, iPTH, ALP, LA, LVDd in VC group were significantly higher than those in no VC group( all P<0.05) .Logistic regression found that PTH and LA were the in-dependent factors for VC.Conclusions The incidence of VC in refractory SHPT are high, The level of iPHT is the inde-pendent impact factors for VC in refractory SHPT.Such patients should be considered for PTX as early as possible in order to slow the progress of VC and improve prognosis.关键词
尿毒症/继发性甲状旁腺功能亢进症/心脏瓣膜钙化Key words
uremia/refractory secondary hyperparathyroidism/heart valve calcification分类
医药卫生引用本文复制引用
王艺萍,赵娜,覃莲香,肖跃飞,张凌..尿毒症继发难治性甲状旁腺功能亢进症患者心脏瓣膜钙化情况及影响因素[J].山东医药,2014,(35):19-22,4.基金项目
北京市科技计划课题（ D101100050010025）。 （）
